Frazier Healthcare files to raise a $400 million venture fund

Frazier Healthcare, a  21-year-old venture capital firm with offices in Seattle and Silicon Valley, has filed documents with the Securities and Exchange Commission to raise up to $400 million for its seventh venture fund.

The firm was founded by former Immunex Chief Financial Officer Alan Frazier, and now includes general partners James Topper, Patrick Herron, Nathan Every, Nader Naini and Robert More. Since it was founded, Frazier Healthcare has invested in more than 140 companies, with 27 companies going public and 54 being acquired.  It is currently investing out of a $600 million fund formed in 2008.

Some of its Seattle investments have included Calistoga Pharmaceuticals; Trubion Pharmaceuticals and Zymogenetics.

The news follows a new level of activity in the Seattle venture capital circles. Last month, Madrona Venture Group announced a new $300 million fund, the largest in the firm’s history. The W Fund — an offshoot of the University of Washington’s Center for Commercialization that aims to fund startups with ties to research organizations in the state— and Divergent Ventures also have closed on new funding in recent months. Meanwhile, Voyager Capital said late last year that it is looking to raise up to $125 million.

We’ve reached out to partners at Frazier Healthcare about the filing, and we’ll update the post as we hear more.